Two new species of Cyriocosmus (Theraphosinae) from Perú are described and illustrated. Both differ from most other species of Cyriocosmus in the absence of a stripped pattern on the abdomen and males with the retrolateral branch of tibial apophysis distally incrassate and flattened. The cladistic relationships within the genus are reanalyzed including these new taxa. Specimens of the new species were collected at altitudes of between 2200 and 3000 m, these records constituting the highest altitudinal record for the genus.